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diagnosis differential nephrology rheumatology vasculitis glomerulonephritis nephrotic testing workup champs classification disease hematology initial membranoproliferative mnemonic mpgn nephritis pathophysiology progressive
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... Urticarial #Vasculitis #HUV
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... A - Atypical HUS ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
formation along glomerular ... staining (lg + complement ... ) • Ex: HCV, HBV ... MGPN • Complement ... glomerulopathy, radiation nephritis
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
in monitoring low-level ... or alternative complement ... antibody, and HIV ... glomerulonephritis #nephrotic ... #nephritic #nephrology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... : - Kidneys: glomerular ... against MPO • Complement ... (Low levels mixed
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Algorithm - Approach ... presenting with overt glomerular ... clusters because nephritic ... #Algorithm #differential ... #proteinuria #nephrotic
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low ... Complement: Post-strep ... GN, Lupus Nephritis ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
in monitoring low-level ... or alternative complement ... antibody, and HIV ... testing #nephrology #nephrotic ... #nephritis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
• Kidneys: Non-glomerular ... HTN • Check: HBV ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic
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