17 results
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... Urticarial #Vasculitis #HUV
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... A - Atypical HUS ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... Coronary arteries - Fever ... Vasculitis: • Fevers ... against MPO • Complement
ID Approach to Fever and Rash - Diagnostic Algorithm
Central Maculopapular (most common):
Measles, Parvovirus 819 / EBV,
ID Approach to Fever ... Rash - Diagnostic Algorithm ... Viral hemorrhagic fevers ... (Pseudomonas, mold ... Febrile #Diagnosis #Algorithm
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Positive Coombs testing ... post infectious setting ... Mycoplasma, EBV, HIV ... temperatures by fixing complement ... Symptoms: High fevers
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Differential Diagnosis Algorithm ... Warm AIHA • Cold ... perfringens - Complement-Mediated ... • Cold AIHA ... MAHA (TTP, DIC, HUS
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... Agglutination - Cold ... DIC, TTP, HELLP, HUS ... bartonella (oroya fever ... workup #hematology #testing
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis: • Fevers ... and branches • Fever ... HTN • Check: HBV ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic
Chest Pain Diagnosis and Management Algorithm
STEMI:
 - Hx: Pressure like CP, Radiation to arm/jaw, CAD risk
and Management Algorithm ... onset, severe, tearing ... friction rub, Fever ... caustic ingestion, HIV ... , Dyspnea, H/O COPD
Neurological Manifestations of Tuberculosis
Spinal Arachnoiditis & Polyradiculopathy:
 • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
dysfunction, muscle wasting ... (IRIS): • In HIV ... neurologic symptoms, fever ... ) • Headache, fever ... Meningitis: • Fever