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diagnosis rheumatology differential huv management urticarial classification glomerulonephritis henochscholeinpurpura hsp igg4 progressive rapidly rpgn signs symptoms vasculitides
Diagnosis and Management of Hypocomplementemic Urticarial Vasculitis (HUV) Diagnosis of HUV 1) Chronic urticaria 2) Leukocytoclastic vasculitis 3)
Management of Hypocomplementemic ... Urticarial Vasculitis ... 3) Hypocomplementemia ... Rituximab, anti-IgE ... TerrierBen #Hypocomplementemic
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... #HUV #Pathophysiology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis and Vasculitides ... Schonlein Purpura (IgA ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
IgA Vasculitis – ... Activation of complement ... Leukocytoclastic vasculitis ... Cutaneous small vessel vasculitis ... #Pathophysiology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... staining): • Low Complement ... : IgA nephropathy ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Schonlein Purpura (IgA ... Ig A nephropathy ... , IgA (cmpkx deposits ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
IGG-4 RELATED DISEASE ... dysfunction PATHOPHYSIOLOGY ... aortitis, mimics vasculitis ... , ↓ complement ... -2.5 g/day #IGG
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