11 results
Diagnosis and Management of Hypocomplementemic Urticarial Vasculitis (HUV)

Diagnosis of HUV
1) Chronic urticaria 
2) Leukocytoclastic vasculitis 
3)
Management of Hypocomplementemic ... vasculitis 3) Hypocomplementemia ... TerrierBen #Hypocomplementemic
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Soluble antigen - Allergen-specific ... When the specific allergen ... antigen, leading to complement ... Complement activation ... Pathophysiology #Allergy
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Mechanism of Action: Allergen-specific ... antigens, leading to complement ... they activate complement ... reactions #types #allergy
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
rheumatoid factor), ± hypocomplementemia
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic
Type II Hypersensitivity: Pathogenesis and clinical findings
Definition: When antigens bind to the body's cell surfaces, forming
activates the complement ... HypersensitivityReaction #Allergy
Complement 1 esterase inhibitor (C1-INH) Deficiency Testing Algorithm
INDICATIONS FOR TESTING:
 • Recurrent angioedema (without urticaria)
 •
Complement 1 esterase ... ARUPLabs #C1INH #Complement ... Testing #Algorithm #allergy