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diagnosis rheumatology erythematosus lupus vasculitis agglutinin anemia c4 champs classification cold criteria disease hemolytic low mnemonic polycythemia slicc systemic vasculitides
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Cryoglobulinemia (85%), C3 ... @AnnKumfer #Hypocomplementemia ... #Low #Complement ... #hematology
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Selected Diseases on Complement ... Levels - C3, C4 ... • SLE C3 ↓ C4 ... #Levels #C3 #C4 ... #differential #
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... CRITERIA - ANA level ... anticoagulant - Low complement ... (C3, C4, or CH50 ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed ... vasculitis, and SLE
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... permanent alopecia Differential ... Malignancy (e.g. hematologic ... levels (C3 and ... disease activity • C3
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... Diagnosis Algorithm ... Better call hematology ... some time, let’s see ... #workup #hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... diseases, such as SLE ... Vasculitis: • Fevers ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
hemolysis • C3 ... younger pts) Differential ... temperatures by fixing complement ... Symptoms: High fevers ... hemolytic #anemia #hematology
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