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diagnosis differential ahus c4 champs classification hematology hemolytic low mimics mnemonic pulmonary renal rheumatology syndrome syndromes uremic vasculitides vasculitis
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Cryoglobulinemia (85%), C3 ... HUS, autoimmune ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Selected Diseases on Complement ... Levels - C3, C4 ... • SLE C3 ↓ C4 ... ↓ C4 → • HUS ... #Levels #C3 #C4
Atypical HUS - Hemolytic Uremic Syndrome Unlike typical HUS, which is shigatoxin mediated, aHUS is not typically
Atypical HUS - Hemolytic ... autoimmune like SLE ... It is complement ... need the ADAMTS13 level ... with Eculizumab (complement
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
anti-GBM) 10%: - Low Complement ... Levels: SLE, Cryoglobulinemic ... Levels: Scleroderma ... hypertension - MAHA: HUS ... , atypical HUS,
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed ... vasculitis, and SLE
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