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Type 2 Diabetes - Screening, Diagnosis and Management Algorithm Lifestyle Modifications (Diet and Exercise) -> Start
-> Start Oral Hypoglycemic ... Second Oral Hypoglycemic ... Recurrent severe hypoglycemia ... relative with DM2 ... Amy Chung, MD, MSc
Metformin Pharmacology Summary Mechanisms of Action: • Suppresses gluconeogenesis by the liver • Increases insulin-mediated glucose utilization
Does not cause hypoglycemia ... mL/minute/1.73 rm2 ... mL/minute/1.73 m2 ... Pharmacology #Summary #DM2
INSULIN CONVERSION Total daily dose of insulin (TDD) =
& most type 2 DM ... or at risk for hypoglycemia ... insulin #diabetes #hyperglycemia ... #dm2 #basalinsulin
Sulfonylureas - Pharmacology Summary Mechanisms of Action: Binds to the ATP-sensitive potassium channel in pancreatic beta cells,
: Weight gain, Hypoglycemia ... Pharmacology #Summary #DM2
Oral Hypoglycemics in Diabetes Management 1 INSULIN SENSITIZER • TZD -
Oral Hypoglycemics ... Amy Chung, MD, MSc ... AmyChung #Oral #Hypoglycemics ... #pharmacology #DM2
Pathophysiology of Diabetic Ketoacidosis (DKA) and Hyperglycemic Hyperosmolar Syndrome (HHS) Absolute Insulin deficit: - Type I DM:
deficit: - Type I DM ... produced - Type II DM ... food binges, etc Hyperglycemia
Severity of Aortic Stenosis in Adults Current ACC/AHA guidelines recommend cut-off values for Doppler-echocardiographic measurements of
area (AVA) <1.0 cm2 ... surface area <0.6 cm2 ... /m2, mean gradient ... common problem in clinical ... combination of an AVA <1 cm2
Hyperglycemia - Differential Diagnosis Algorithm Diabetes Mellitus: • Impaired Glucose Tolerance • Type I Diabetes • Type
Hyperglycemia - ... agonists • Others Critical ... Stress: • Stress Hyperglycemia ... Infarction #Hyperglycemia
DPP4 Inhibitors - Normal and Renal Dosing Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
minimal chance of hypoglycemia ... Management #Diabetes #DM2
GLP-1 Agonists Adlyxin (Lixisenatide) Daily Bydureon (Exenatide ER) Weekly Ozempic (Semaglutide) Weekly Trulicity (Dulaglutide) Weekly Victoza (Liraglutide) Daily
a low risk of hypoglycemia ... Dosing #Diabetes #DM2
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