8 results
Sulfonylureas - Pharmacology Summary
Mechanisms of Action: Binds to the ATP-sensitive potassium channel in pancreatic beta cells,
: Weight gain, Hypoglycemia ... Pharmacology #Summary #DM2 ... #diabetes #endocrinology
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Does not cause hypoglycemia ... mL/minute/1.73 rm2 ... mL/minute/1.73 m2 ... Pharmacology #Summary #DM2 ... #diabetes #endocrinology
Pathophysiology of Diabetic Ketoacidosis (DKA) and Hyperglycemic Hyperosmolar Syndrome (HHS)
Absolute Insulin deficit:
 - Type I DM:
deficit: - Type I DM ... produced - Type II DM ... food binges, etc Hyperglycemia ... pathophysiology #comparison #endocrinology
Causes of Provoked Pediatric Seizures - Differential Diagnosis Algorithm - "DIMS" Mnemonic
Drugs:
 • Drug overdose
 •
Algorithm - "DIMS" Mnemonic ... Metabolic: • Hypoglycemia ... • Hyperglycemia ... Syndrome #DIMS #Mnemonic ... Algorithm #Causes #Peds
DPP4 Inhibitors - Normal and Renal Dosing

Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
minimal chance of hypoglycemia ... Management #Diabetes #DM2 ... #Endocrinology
GLP-1 Agonists

Adlyxin (Lixisenatide) Daily
Bydureon (Exenatide ER) Weekly 
Ozempic (Semaglutide) Weekly 
Trulicity (Dulaglutide) Weekly 
Victoza (Liraglutide) Daily
a low risk of hypoglycemia ... Dosing #Diabetes #DM2 ... #Endocrinology
Assessment of diabetic control:
 - Any episodes of hypoglycaemia, diabetic ketoacidosis, hospital admission? 
 - Is
Any episodes of hypoglycaemia ... still awareness of hypoglycaemia ... #primarycare #DM1 ... #Peds #Pediatrics
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Hyperkalemia, Hypoglycemia ... pathophysiology #genetics #endocrinology ... #peds #pediatrics