12 results
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
- Differential ... malignancies • Anemia ... inflammatory disorders ... Myelodysplastic syndrome ... Diagnosis #Causes #hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
- Markers and Differential ... , Auer rod • Lymphoid ... T-cell - CD7, CD3 Chronic ... Pelger-Huet, Macrocytic anemia ... #hematology #Markers
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... Metastatic cancer, Lymphoma ... • Infections: Chronic ... Diagnosis #Algorithm #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
basophilia, and thrombocytosis ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
leukemia in adults • Disorder ... to large cell lymphoma ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Epidemiology: • Most common ... lymphoproliferative disorders ... • Neutropenia, anemia ... diagnosis #workup #oncology ... #hematology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... hepatitis • Lymphoma ... • Nodules • Lymphoid ... autoimmune hemolytic anemia ... hypogammaglobulinemia #immunology #hematology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... (NSHL) - (most common ... Immunohistochemical studies (to differentiate ... classification #hematology ... #oncology #management
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... or lymphoid malignancy ... symptoms - most common ... younger pts) Differential ... #hematology #diagnosis
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Most common cytopenia ... Marrow Failure • Chronic ... blood count with differential ... #diagnosis #hematology ... #oncology