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algorithm leukemia aplastic classification cll common cvid elevatedmcv hypogammaglobulinemia immunodeficiency immunology macrocytic macrocytosis markers mcv mds morphologic secondary variable workup
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... vera (PV) • Myelodysplastic ... syndrome • Myelofibrosis ... Diagnosis #Causes ... #hematology #secondary
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Blood Disorders ... T-cell - CD7, CD3 Chronic ... - Myelodysplastic ... Pelger-Huet, Macrocytic anemia ... #Disorders #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
caused by blood ... Marrow Failure • Chronic ... count with differential ... #Syndromes #diagnosis ... #hematology #oncology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
disease, Acute blood ... Hypothyroidism, Myelodysplastic ... syndrome - Dr ... #diagnosis #causes ... #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Normal Blood Smear ... Dysplastic • Myelodysplastic ... Syndromes Macrocytosis ... #Causes #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... • Neutropenia, anemia ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... #oncology #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Immunohistochemical studies (to differentiate ... #lymphoma #diagnosis ... classification #hematology ... #oncology #management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... • Hypocellular myelodysplastic ... syndrome (MDS) ... #oncology #hematology ... #diagnosis #management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
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