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algorithm causes injury transaminitis acute cirrhosis aclf aih chemistry common cvid dili druginduced failure fatigue function gastroenterology hepatocellular hepatomegaly hypogammaglobulinemia
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
5-10x normal - Chronic ... #Injury #hepatology ... #LFTs #transaminitis ... #differential # ... diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Differential Diagnosis ... Cirrhosis • Chronic ... Viral Hepatitis ... • Acute Viral Hepatitis ... Diagnosis #hepatology
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Infectious • Hepatitis ... Hepatitis • Autoimmune ... Hepatitis • Drug ... Induced Hepatitis ... #Causes #Hepatology
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Inflammation - Hepatitis ... 15 percent) - Hepatitis ... heart failure (chronic ... #Differential # ... Hepatology #Cirrhosis
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 Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Ischemia • Autoimmune ... hepatitis • Drugs ... • Others #LFTs ... #Hepatology #LiverEnzymes
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
• Infectious: Hepatitis ... hepatitis, Acute ... Hepatitis, TPN ... Sepsis, Viral Hepatitis ... Acute #algorithm #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Infections: Hepatitis ... Drugs (MDMA), Alcohol ... #Diagnosis #hepatology ... Transaminitis #LFTs ... #hepatitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Failure Infections Alcohol-Associated ... Hepatitis (AAH) ... (DILI) Viral Hepatitis ... #Cirrhosis #Hepatology ... #diagnosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
HEV, EBV, CMV), Alcohol-related ... hepatitis fibrosis ... steatosis • Autoimmune ... hepatitis #DILI ... #Algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Check Acute viral hepatitis ... Check Acute viral hepatitis ... viral hepatitis ... #differential # ... Hepatology #transaminitis
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