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diagnosis aplastic chronic hemolytic lymphocytic management mds myelodysplasia myelodysplastic petechiae petechial physicalexam protein proteingap rash secondary syndromes testing
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Chronic Myelogenous Leukemia ... malignancy • Iron deficiency ... anemia #Thrombocytosis ... #Causes #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic Anemia ... Leukemia, Tumour ... ITP • SLE • CLL ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... specifically: iron deficiency ... Chronic myeloid leukemia ... #hematology #secondary
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
activity • ↓ LAP ... basophilia, and thrombocytosis ... - infiltrates (anemia ... , thrombocytopenia ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... , thrombocytopenia ... increase in gamma globulins ... #diagnosis #workup ... #oncology #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Consider sickle cell ... Schistocytes, thrombocytopenia ... #workup #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... globulin gap (> ... gastric tumors • Hematology ... anemia • Other ... #diagnosis #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
infections/fevers • Thrombocytopenia ... and petechiae Causes ... virus (EBV) • Leukemia ... antithymocyte globulin ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Workup: • Complete ... blood count with differential ... Syndromes #diagnosis #hematology ... #oncology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Rash - Differential ... hemostasis: - Thrombocytopenia ... Work Up: • ... #Causes #dermatology
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