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management lupus oncology syndrome chronic classification cll druginduced erythematosus leukemia lymphocytic systemic algorithm cerebritis cns comparison cryoglobulinemia cryoglobulins dermatology differential
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
40, F:M 9:1 • Clinical ... • Immunologic Workup ... life-threatening • Treatment ... Evolution: Chronic disease ... #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... : SLE+++, Adult-onset ... Still disease, ... Treatment: • ... #summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Discontinuation of causal ... Evolution: Chronic disease ... comparison #table #rheumatology ... #diagnosis #management
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... ) Clinical Manifestations ... Cerebrovascular Disease ... autoantibodies that will cause ... CNS #neurology #rheumatology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) - Summary ... immunophenotype Clinical ... chemotherapy for low-risk disease ... Leukemia #oncology #hematology ... #hemeonc #diagnosis
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
complex → plt activation ... : • Clinical Suspicion ... Confirmatory test ↑Se ... #Management #Treatment ... #Hematology #HemeOnc
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Better call hematology ... some time, let’s see ... As with many disease ... #Algorithm #workup ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus [SLE ... Treatment: • Corticosteroids ... #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytic Leukemia - Summary ... Orange or Hep C Clinical ... cells can indicate disease ... #workup #oncology ... #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia Summary ... • They can cause ... Syndrome: • Clinical ... • Autoimmune diseases ... classification #rheumatology
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