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hematology causes algorithm comparison oncology basophilia basophils cll compared dehydrogenase diseases elevated eosinophilia eosinophilic erythemas erythematosus immunecompromised immunocompromised laboratory lactate
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Myelogenous Leukemia ... Myelofibrosis Infectious ... : • Acute or Chronic ... disorders • Celiac disease ... #Causes #Hematology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Basophilia - Differential ... Diagnosis Framework ... Disorders: • Chronic ... Colitis and Crohn’s Disease ... #hematology #basophils
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... extramedullary disease ... Headaches, bone pain, fever ... #Hematology #Oncology ... #Diagnosis
Approach to Eosinophilic Lung Diseases • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
• Acute Eosinophilic ... , CNS, skin • Infectious ... #pulmonary #differential ... #diagnosis #comparison ... #table #eosinophilia
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... Diagnosis Algorithm ... • Periodontal Disease ... Bronchitis • Chronic ... #Causes #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... weeks without infection ... lymphocyte > 5000/microL ... ’s lymphoma or acute ... #oncology #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- APLS • Acute ... Streptococcus pneumoniae ... mountain spotted fever ... #Diagnosis #hematology ... #nonpalpable #dermatology
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
fires, heating pads ... early localized disease ... Erythemas #comparison #table ... #differential # ... diagnosis #dermatology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... Diagnosis Framework ... • Toxins • Infection ... myocarditis, rheumatic fever ... Lymphomas • Leukemias
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... permanent alopecia Differential ... fibromyalgia) • Infections ... with Lupus: • Chronic ... Hodgkin lymphoma and leukemia
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