8 results
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
, difficult to diagnose ... Life-threatening ... BrighamChiefs #AdultOnset ... #rheumatology # ... diagnosis #management
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad: Fever ... hepatitis • Pulmonary ... Prunelle Getten #AdultOnset ... #management #treatment ... #rheumatology
Endocarditis checklist
Initial evaluation
 • Peripheral blood cultures (three sets at three different sites)
 • Additional culture
Endocarditis checklist ... endocarditis w/ septic pulmonary ... • Persistent fever ... #criticalcare #diagnosis ... #management
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
• Leukocytosis Diagnosis ... • If uncontrolled ... Stills #disease #AOSD ... #diagnosis #rheumatology ... #management
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Prophylaxis: • Attempt if ... high risk if WBC ... Subacute-Acute: • Common: fever ... Imaging: CXR- pulmonary ... #management #hematology
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
symptoms • Rheumatologic ... Increased protein level ... normal glucose level ... device removal (if ... #Management #Infections
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
night sweats, fever ... Cerebral > Splenic, pulmonary ... Differential Diagnosis ... Paradoxical emboli via ASD ... #management #cardiology
Severe Influenza Checklist

Diagnostic tests 
 - Blood cultures x2 
 - Sputum gram stain & culture
Severe Influenza Checklist ... Diagnostic tests ... - Ferritin, liver ... lab-confirmed influenza, pulmonary ... #Management #CriticalCare