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hematology hemophagocytic lymphohistiocytosis blood product reactions treatment admissions admitting apml classification crisis differentiation endocarditis hemeonc hodgkins icu influenza lymphoma myastheniagravis
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... • Clinical: fever ... , ↓ Fibrinogen level ... #management #treatment ... #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
following: • Fever ... lymph node, or liver ... If no response HLH ... #management #treatment ... #hematology
Pancreatitis management checklist Evaluation to guide etiology & management - RUQ ultrasound - Calcium
checklist Evaluation ... ultrasound - Calcium level ... - Triglyceride level ... #Diagnosis #Management ... #CriticalCare
Endocarditis checklist Initial evaluation • Peripheral blood cultures (three sets at three different sites) • Additional culture
Endocarditis checklist ... • Persistent fever ... #Endocarditis #checklist ... #criticalcare # ... diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... diagnostic consideration ... Diagnostic Criteria ... Approach • Initial management ... #Management #Hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... lymph node biopsy (diagnostic ... marrow biopsy - if ... Hodgkins #lymphoma #diagnosis ... #oncology #management
Myasthenic Crisis Checklist - Myasthenia Gravis Evaluation - Chest X-ray and lung ultrasound (exclude other lung
Myasthenic Crisis Checklist ... workup or TSH level ... Pyridostigmine - New diagnosis ... MyastheniaGravis #Checklist ... #Management #CriticalCare
Admitting in the ICU - Checklist VITALS: If bad, stop and go see the patient immediately; you
Admitting in the ICU - Checklist ... esp in work-up/management ... bedside echo is never ... #diagnosis #workup ... #criticalcare
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Prophylaxis: • Attempt if ... high risk if WBC ... Subacute-Acute: • Common: fever ... #management #hematology ... #oncology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
S/sx: Fever, flank ... thrombocytopenia, may be life-threatening ... donors (due to anti-HLA ... #Transfusion #diagnosis ... #management #hematology
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