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hematology hemophagocytic hlh lymphohistiocytosis treatment disease product reactions aosd apml chagas classification differentiation hemeonc hodgkins lymphoma onset stills summary syndrome
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
frequently affects infants ... also observed in adults ... acute or subacute febrile ... #management #treatment ... #hematology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... extremities during febrile ... • If uncontrolled ... #rheumatology # ... management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Phagocytosis of blood ... , ↓ Fibrinogen level ... diseases: SLE+++, Adult-onset ... #management #treatment ... #summary #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
high risk if WBC ... Subacute-Acute: • Common: fever ... Rare: DAH, acute febrile ... #management #hematology ... #oncology
Chagas Disease - American Trypanosomiasis - Diagnosis and Management Summary Chagas disease (American trypanosomiasis) is an infectious
Trypanosomiasis - Diagnosis ... and Management ... Blood (platelets ... mild (malaise, fever ... Regimens: • Adult
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Mediated: - Febrile ... S/sx: Fever, flank ... thrombocytopenia, may be life-threatening ... #Transfusions #diagnosis ... #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... Mediated: • Febrile ... thrombocytopenia, may be life-threatening ... #Transfusion #diagnosis ... #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
consideration in febrile ... to find in an adult ... Onset: Usually in infancy ... - Common in: Adults ... #Management #Hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
history • Young adults ... • Dyspnea • Fever ... Workup: • Full Blood ... blood abnormalities ... #oncology #management
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