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oncology treatment anemia blood hemophagocytic hlh lymphohistiocytosis product reactions syndrome adult algorithm antibiotics aosd apml classification differentiation disease fever hodgkins
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... neutropenic fever ... #Anemia #diagnosis ... #management #treatment ... #hematology
The Febrile Infant Step-by-Step Algorithm This is an algorithm developed by European emergency physicians to identify low-risk
The Febrile Infant ... 92.0% and 46.9% #Diagnosis ... #EBM #Management ... #Pediatrics #Peds ... #Febrile #Infant
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Toxic injury to BM ... Presentation: • Fever ... index < 2 • EPO Level ... Anemia #oncology #hematology ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
frequently affects infants ... acute or subacute febrile ... If no response HLH ... #management #treatment ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... • Clinical: fever ... , ↓ Fibrinogen level ... #management #treatment ... #summary #rheumatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
• Leukocytosis Diagnosis ... extremities during febrile ... • If uncontrolled ... #rheumatology # ... management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Prophylaxis: • Attempt if ... high risk if WBC ... Subacute-Acute: • Common: fever ... Rare: DAH, acute febrile ... #management #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... Treatment: - If ... febrile, give abx ... Syndrome #TLS #diagnosis ... #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Mediated: • Febrile ... thrombocytopenia, may be life-threatening ... due to marrow aplasia ... #Transfusion #diagnosis ... #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Mediated: - Febrile ... thrombocytopenia, may be life-threatening ... due to marrow aplasia ... #Transfusions #diagnosis ... #management #hematology
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