6325 results
The interferon (IFN) signature: what’s the point? How to use it in clinical practice?

Characterizing activity of
The interferon (IFN ... How to use it in ... Characterizing activity of IFN ... Limitations of the IFN ... #interferon #IFN
Tuberculous Pleural Effusions - Tests and Biomarkers
Age + fever + red blood cells + ADA -
specificity ADA + IFN-y ... NAAT - Increase in ... adenosine deaminase; IFN
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
of CD8 T cells (IFN-y ... (100 mg/m2) : in ... emergency, ICU in ... manifestations, Anti-IFN-y
Fever - Pyrogen Pathophysiology

EXOGENOUS PYROGEN
 • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins
 •
pyrogen) TNF, IL-1, IFN ... fenestrated capillaries in ... stimulates cAMP in
Rigors And Bacteremia - Overview

• Rigors are a response to the release of cytokines and prostaglandins
chills were helpful in ... bacteremia • Chills in ... Pyrogen (TNF, IL-1, IFN ... fenestrated capillaries in ... stimulates cAMP in
Mycosis Fungoides - Therapy Escalation

Later stage MF requires collaboration with an oncologist

Topical Steroids 
Nitrogen Mustard 
Bexarotene
Pralatrexate (Folotyn) IFN
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
IFN-γ-activated ... ) have no role in
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
consideration in ... Onset: Usually in ... : - Common in ... cytokines (e.g., IFN-γ ... inhibitors, anti-IFN
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
IFN-γ-activated ... ) have no role in
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
Syndrome Step 1: If ... dysmorphic RBCs in