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Cryoglobulinemia Classification Types Type 1: Monoclonal IgM (rarely IgG/lgA) • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
Classification Types ... IgM (rarely IgG ... and polyclonal IgG ... and polyclonal IgG ... and polyclonal IgG
Types of hypersensitivity reactions Type I - lgE-Mediated, Within I Hour (Anaphylaxis) Type II - IgG or IgM
Types of hypersensitivity ... reactions Type ... (Anaphylaxis) Type ... II - IgG or IgM ... Serum Sickness) Type
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Hypersensitivity Types ... II - IgG or IgM ... Cell-bound antigen - IgG ... IgG can also mediate ... Type Ill - IgG and
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Hypersensitivity: Summary Type ... conjunctivitis Type ... Mediator: IgM + IgG ... Graves' Disease Type ... Immunological Mediator: IgG
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of types ... Type 1 - Mediators ... Eczema, Asthma Type ... - Mediators: IgG ... Mechanism of Action: IgG
Treatment of Non-hepatitis C virus Cryoglobulinemia Vasculitis - French Vasculitis Study Group MONOCLONAL CRYOGLOBULINEMIA (TYPE 1) IgM
CRYOGLOBULINEMIA (TYPE ... chloraminophene IgG ... CRYOGLOBULINEMIA (TYPES
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
IGG-4 RELATED DISEASE ... infiltration of IgG4 ... lesions - IgG4 ... • Pancreas: Type ... Biliary Tract: IgG4
Subtypes of Serum Proteins Pre-albumin (Transthyretin) Albumin Globulins • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
• Gamma: IgM, IgG ... classification #Types
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
Type II Hypersensitivity ... autoimmune antibodies (IgG ... cell surfaces #Type2 ... #Type2 #HypersensitivityReaction
Pulmonary Aspergillosis Main Culprits: Aspergillus fumigatus, Less commonly: Aspergillus flavus, Aspergillus terreus Diagnosis: Characteristic imaging + symptoms +
serum Aspergillus IgG ... aspergillus #diagnosis #types
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