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diagnosis management oncology rheumatology algorithm differential druginduced hemophagocytic hlh lupus lymphohistiocytosis mds myelodysplastic summary anemia antinxp2 antinxp2dm arthritis cancer chronic
Algorithm for the Evaluation and Management of Sickle Cell Crises Clinical Manifestations and Management #Diagnosis #Management #Hematology #SickleCell
Algorithm for the Evaluation ... Management of Sickle Cell ... Crises Clinical ... Diagnosis #Management #Hematology ... #Algorithm #Ddxof
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... aplasia • ITP ... microglobulin Treatment ... Leukemia #diagnosis #workup ... #oncology #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... = funny-shaped cells ... old, ~10,000 new cases ... Allogeneic stem cell ... #hematology #oncology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
during medical evaluation ... or workup for specific ... /µL Workup • Screen ... glucocorticoid treatment ... Differential #diagnosis #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... formed or don’t work ... • Anemia • Aplastic ... Workup: • Complete ... Syndromes #diagnosis #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Anemia Clinical ... and petechiae Causes ... number of CD34+ cells ... anemia Treatment ... Anemia #oncology #hematology
Septic Arthritis - Diagnosis and Management Summary Clinical Exam: hot, swollen, pain with passive AND active ROM
viral arthritis Workup ... culture, Gram stain, cell ... count, and crystal evaluation ... Ciprofloxacin • Sickle Cell ... MH/CCF/CWRU EM
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... ++: Hodgkin, T-cell ... lymphoma, B-cell ... Treatment: • ... inhibitors under evaluation
When to look for clonal/neoplastic hypereosinophilia (HEo)? - Exclusion of frequent causes (Drug-induced HEo, helminthiasis, cancer,
Exclusion of frequent causes ... ) - Clinical symptoms ... Cytopenia, Other cell ... Diagnosis #Signs #Hematology ... #Workup
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Epidemiology: -10% of all ... to 1:1 F:M • Clinical ... • Immunologic Workup ... 40, F:M 9:1 • Clinical ... • Immunologic Workup
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