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hyperkalemia management diagnosis causes differential pharmacology binders diuresis diuretics excretion k methotrexate rhabdomyolysis toxicity
Hyperkalemia Treatment Options Stabilize cardiac membrane: • IV Calcium (peaks 5-10 minutes) Decrease potassium concentration: • IV Fluids Shift
Hyperkalemia Treatment ... concentration: • IV Fluids ... Shift potassium ... (if preserved renal ... #nephrology
Potassium Binders for Management of Hyperkalemia • SPS - Sodium polystyrene sulfonate • Patiromer (veltassa) •
Potassium Binders ... cyclosilicate #Potassium ... #Hyperkalemia #treatment ... #pharmacology #table ... #comparison #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... • Recent IV potassium ... Medications 2. ... diagnosis #causes #potassium ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... • Recent IV potassium ... Medications 2. ... diagnosis #causes #potassium ... #high #nephrology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
oxidative injury Treatment ... Treatment of underlying ... Monitor potassium ... per day until stable ... #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Etiology: • Medications ... 15 suggests ↓ renal ... Elimination (see Table ... STOP offending medications ... #potassium #nephrology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
Loop Diuretics; High-Ceiling ... Tolvaptan) • Treatment ... Excretion #Diuresis #Nephrology ... #Pharmacology #Medications ... #Table
Methotrexate Renal Toxicity Prevention: • Alkalinize the urine, keep urine ph >7 • Start pre-treatment 12
Methotrexate Renal ... bicarbonate based fluids ... clearance but high ... #Methotrexate #Renal ... #nephrology
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