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management diagnosis differential gastroenterology hematology nephrology cardiology rheumatology disease pulmonary hepatology oncology neurology syndrome causes guidelines types vasculitis ibd infectiousdiseases
Subtypes of Serum Proteins Pre-albumin (Transthyretin) Albumin Globulins • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Transferrin • Gamma: IgM ... , IgG, IgA, RF, ... Proteins #Subtypes #algorithm ... #classification
Cryoglobulinemia Classification Types Type 1: Monoclonal IgM (rarely IgG/lgA) • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
Cryoglobulinemia Classification ... (rarely IgG/lgA ... and polyclonal IgG ... and polyclonal IgG ... Cryoglobulinemia #Classification
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
allergies Type II - IgG ... antigen - IgG ... IgG can also mediate ... Type Ill - IgG and ... Hypersensitivity #Types #Classification
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
• Mechanism: IgG ... Coombs positive for IgG ... Spherocytes • Treatment ... • Mechanism: IgM ... transient hemolysis • Treatment
Types of hypersensitivity reactions Type I - lgE-Mediated, Within I Hour (Anaphylaxis) Type II - IgG or IgM
Anaphylaxis) Type II - IgG ... or IgM Cytotoxic ... reactions #Types #Classification
Management of adult IgA Vasculitis (Henoch-Schönlein purpura) - Treatment algorithm for the management of IgAV patients
Henoch-Schönlein purpura) - Treatment ... algorithm for the ... Treatment remains ... HSP #Management #Treatment ... Rheumatology #Vasculitis #Algorithm
Commonly Used Diagnostic Tests for Celiac Disease Tissue transglutaminase (tTG) IgA antibodies - Most reliable noninvasive test
negative with IgA ... transglutaminase (tTG) IgG ... patients with IgA ... antibody test IgG ... Reflects response to treatment
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Immunological Mediator: IgM ... + IgG • Immunological ... Immunological Mediator: IgG ... Reactions #Types #Classification
Celiac Disease Testing Algorithm INDICATIONS FOR TESTING: Nonspecific symptoms (iron-deficiency anemia, failure to thrive, fever, skin
Disease Testing Algorithm ... • tTG IgG and ... DGP IgGa • EMA ... IgG by IFA • DGP ... Disease #Testing #Algorithm
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
IGG-4 RELATED DISEASE ... infiltration of IgG4 ... lesions - IgG4 ... Biliary Tract: IgG4 ... complement • Classification
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