1278 results
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
antigen - IgG ... IgG can also mediate ... Type Ill - IgG and ... Hypersensitivity #Types #Classification ... #Pathophysiology
IGG-4 RELATED DISEASE

WHAT?
 • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
IGG-4 RELATED DISEASE ... dysfunction PATHOPHYSIOLOGY ... lesions - IgG4 ... Biliary Tract: IgG4 ... complement • Classification
Cryoglobulinemia Classification Types

Type 1: Monoclonal IgM (rarely IgG/lgA)
 • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
Cryoglobulinemia Classification ... (rarely IgG/lgA ... and polyclonal IgG ... and polyclonal IgG ... Cryoglobulinemia #Classification
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Anemia (AIHA) Pathophysiology ... AIHA: - 70%; IgG ... mediated - DAT: IgG ... mediated - DAT: IgG ... Hemolytic #Anemia #Pathophysiology
Subtypes of Serum Proteins

Pre-albumin (Transthyretin)
Albumin
Globulins
 • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Transferrin • Gamma: IgM ... , IgG, IgA, RF, ... Subtypes #algorithm #classification
Types of hypersensitivity reactions

Type I - lgE-Mediated, Within I Hour (Anaphylaxis)
Type II - IgG or IgM
Anaphylaxis) Type II - IgG ... or IgM Cytotoxic ... reactions #Types #Classification
You’ll notice there is an IgM and an IgG core antibody. The presence of IgM anti-HBc
and an IgG core ... IgM anti-HBc is ... The presence of IgG ... infected with HBV, IgG ... and IgG anti-HBc
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Immunological Mediator: IgM ... + IgG • Immunological ... Immunological Mediator: IgG ... Reactions #Types #Classification
Commonly Used Diagnostic Tests for Celiac Disease

Tissue transglutaminase (tTG) IgA antibodies
 - Most reliable noninvasive test
negative with IgA ... transglutaminase (tTG) IgG ... patients with IgA ... antibody test IgG ... patients with IgA
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
IgM MGUS: • Serum ... IgM monoclonal ... myeloma Non-IgM ... or IgG isotype ... (rarely IgD or IgE