28 results
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
produced from normal immune ... a maladaptive immune ... self-antigens are the cause ... antigens are the cause ... Allergy #Immunology #pathophysiology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... immunofluorescence Immune ... Goodpasture's) Pauci-immune
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Manifestations • Immune ... Myopathy (Also caused ... Complications #pathophysiology
Childhood Immunization Schedule: Why we immunize
 • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
Schedule: Why we immunize ... URT inflammation causes ... severe swelling causes ... severe swelling causes ... peds #pediatrics #pathophysiology
Pathogenesis of Rheumatic Fever

Pathogenesis of rheumatic fever. 
1. GAS pharyngitis leads to antigenic presentation of pathogenic
and cellular) immune ... which incites immune ... cytokine-mediated immune ... antibodies which can cause ... Rheumatic #Fever #Pathophysiology
Rigors And Bacteremia - Overview

• Rigors are a response to the release of cytokines and prostaglandins
PATHOPHYSIOLOGY: ... components → Stimulate immune ... Rigors #Bacteremia #Pathophysiology ... #InfectiousDiseases
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but potentially serious adverse reaction that has been
Vaccine-induced immune ... The exact cause ... antibodies which cause ... Vaccine #Induced #immune ... thrombocytopenia #COVID #pathophysiology
Rheumatoid arthritis (RA): Extra-articular manifestations
Skin: 
 • Inflammation of skin (esp. over areas of stress) forms
Nodules • Auto-immune ... Alopecia • Auto-immune ... inflammation tends to cause ... RheumatoidArthritis #RA #pathophysiology
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
a dysregulated immune ... Viral replication causes ... PolyarteritisNodosa #Pathophysiology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... that disrupts immune ... Others: Cellular immune ... Drugs, Unknown cause ... 100 mg/m2) : in case