1399 results
Check point inhibitors and Side Effects - Immune-related adverse events (IRAEs)

What are the side effects?
 -
Side Effects - Immune-related ... - Immune-related ... to months after treatment ... - Most immune-related
Immune Checkpoint Inhibitor Toxicity

Main Toxicities: Colitis,  
Pneumonitis, Skin adverse events, Endocrine dysfunction, 
Hepatitis,  
Myocarditis,
Immune Checkpoint ... Complications and Treatment ... #Immune #CheckpointInhibitor
Summary of Infections in which Steroids play a role in treatment
 • TB meningitis
 • TB
play a role in treatment ... hypoxemia • Immune ... infections #management #treatment
Immune Reconstitution Inflammatory Syndrome (IRIS) - Pathophysiology
Risk factors:
 - Low CD4 count
 - Disseminated OI
 -
Immune Reconstitution ... duration or OI treatment ... pathogen-specific cellular immune ... Medicine @ucsdim #Immune
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
any time during treatment ... muscle injury • Immune-mediated ... need to consider: immune-mediated ... after DC Statin Treatment ... diagnosis #management #treatment
Treatment of Pouchitis
 • Microbiota-associated - Antibiotics (ciproflaxcin, metronidzole, tinidazole, amoxicillin)
 • Immune-mediated - Budesonide, Mesalamines;
Treatment of Pouchitis ... amoxicillin) • Immune-mediated ... ileal #pouchitis #Treatment
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
Hepatitis B - Treatment ... Indications Treatment ... indicated: • Immune ... ), normal ALT Treatment ... history of HCC Treatment
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
that disrupts immune ... Others: Cellular immune ... Unknown cause Treatment ... diagnosis #management #treatment
SKIN RASHES 



Skin rashes can occur from a variety of factors, including infections, heat, allergens, immune
heat, allergens, immune ... important to make treatment
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Unclear, but innate immune ... synovitis (40%) Treatment ... diagnosis #management #treatment