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Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Hypereosinophilic Syndrome ... • Secondary ... suspect underlying hematologic ... disorders • Diagnosis ... #HES #Hematology
Nail Disorders - Primary and Systemic Causes - Differential Diagnosis Algorithm

#NailDisorders #Primary #Secondary #Systemic #dermatology #Differential
Nail Disorders - ... Primary and Systemic ... NailDisorders #Primary #Secondary ... #Systemic #dermatology
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
Joint Disorders ... arthritis - (Reiter’s syndrome ... arthritis - with the skin ... disorder psoriasis ... inflammation is secondary
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Causes == Primary Skin ... • Xerosis (dry skin ... Myelodisplastic syndrome ... Pruritus #primary #secondary ... #dermatology #Differential
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... leakage of RBC's secondary ... Thrombocytopenia: ITP • Secondary ... Kasabach-Merritt syndrome ... Gardner-Diamond syndrome
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... - Purpura - Skin ... reticularis & skin ... Type III Often Secondary ... (e.g. systemic
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Nail Disorders secondary ... to Systemic Diseases ... Grooves • Any systemic ... • Nephrotic syndrome ... #Secondary #dermatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Demyelinating Syndrome ... Headache, Movement disorders ... , Seizure disorders ... APS), Secondary
CLINICAL MANIFESTATIONS 
OF ADRENAL INSUFFICIENCY. 

Primary and secondary adrenal insufficiency:
 - Tiredness, weakness, mental depression
Primary and secondary ... and associated disorders ... Central nervous system ... and associated disorders ... : - Pale skin
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
associated with systemic ... Rare Disorder: ... Musculoskeletal system ... , breast CA - Hematologic ... Treatment: - Systemic