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diagnosis hematology differential management oncology workup anemia blood causes product reactions syndromes bonemarrow chronic cll evaluation failure leukemia lymphocytic mds
Aplastic Anemia and Bone Marrow Failure Syndromes with Pancytopenia Fanconi Anemia Acquired Aplastic Anemia Dyskeratosis Congenita & Telemore Biology
Aplastic Anemia ... Marrow Failure Syndromes ... with Pancytopenia ... lauraebrown #Pancytopenia ... anemia #diagnosis #Hematology
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic
Algorithm for workup ... of thrombocytopenia ... hemolytic uremic syndrome ... , Hematology 2012 ... #Differential #Algorithm
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Neutropenia with Pancytopenia ... Differential Diagnosis Algorithm ... • Toxins • Aplastic ... deficiencies #Pancytopenia ... #Causes #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Differential Diagnosis Algorithm ... HLH syndrome 5. ... FISH • Acquired Aplastic ... marrow failure syndrome ... #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Differential Diagnosis Algorithm ... HLH syndrome 5 ... FISH • Acquired Aplastic ... marrow failure syndrome ... #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Differential Diagnosis Algorithm ... Megakaryopoiesis • Aplastic ... Non-lmmune: • HELLP Syndrome ... #Causes #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
bone marrow + pancytopenia ... Constitutional Syndromes ... infections/fevers • Thrombocytopenia ... • Peripheral Pancytopenia ... Anemia #oncology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Neutropenia, anemia, thrombocytopenia ... Pure red cell aplasia ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... workup #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... platelet count (thrombocytopenia ... Causes • Anemia • Aplastic ... IDUS) • Immune Thrombocytopenia ... #diagnosis #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
purpura & severe thrombocytopenia ... progresses to pancytopenia ... due to marrow aplasia ... diagnosis #management #hematology
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