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Drug-Induced Liver Injury - Pathophysiology
Indirect
Idiosyncratic
Direct

BWH Medicine Chiefs @BrighamChiefs

#DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Drug-Induced Liver ... Pathophysiology Indirect ... Idiosyncratic Direct ... #DrugInduced #Liver
Liver Function Tests (LFTs)
 - Aspartate aminotransferase (AST) 
 - Alanine aminotransferase (ALT) 
 - Alkaline
Liver Function Tests ... Unconjugated (Indirect ... - Conjugated (Direct ... Prothrombin #Liver
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... specific for the liver ... vs bone Bili - Direct ... Obstructive) vs Indirect ... SinaiBmoreIMRes #Liver
The Liver Consult Primer - Guide to calling a consult
HPI:
 - Start with reason for consult
The Liver Consult ... Focus on prior Liver ... plt, INR, GTT, indirect ... MELD - Chronic liver ... US - Prior liver
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... phosphatase (AlkP) - Liver ... nucleotidase - Liver ... bilirubin (TBili) Direct ... Indirect bilirubin
Ephedrine - Anesthesia Pharmacology
Trade Name: Ephedrine
Brand Name(s): Akovaz
Drug Type: Sympathomimetic Catecholamine
Time of Onset: Rapid
Duration of Action:
Mechanism of Action: Direct ... and indirect sympathomimetic ... Metabolized by liver
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Drugs: Direct or ... indirect inhibitory ... drugs (e.g. direct ... • Reduced liver
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Early liver disease ... Direct Xa inhibitors ... Direct or indirect ... inhibitory drugs e.g. direct ... Reduced liver synthesis
Algorithm and Differential Diagnosis of Hyperbilirubinemia 
Direct = Conjugated
Indirect = Unconjugated

#Diagnosis #Jaundice #Hyperbilirubinemia #Differential #Algorithm #Direct
Hyperbilirubinemia Direct ... = Conjugated Indirect ... Differential #Algorithm #Direct ... #Indirect #Conjugated
Coombs Test - Direct vs Indirect

#Diagnosis #Testing #Coombs #Direct #Indirect #Hemolytic #Anemia
Coombs Test - Direct ... vs Indirect # ... Testing #Coombs #Direct ... #Indirect #Hemolytic