11 results
Drugs and Classes Associated with DILI and Type of Liver Injury

#Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
and Type of Liver ... Injury #Medications ... #Differential #DrugInduced ... #LiverInjury #Hepatology ... #DILI
Drug-Induced Liver Injury - Pathophysiology
Indirect
Idiosyncratic
Direct

BWH Medicine Chiefs @BrighamChiefs

#DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Drug-Induced Liver ... Injury - Pathophysiology ... BrighamChiefs #DILI ... #DrugInduced #Liver ... #hepatology
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Causes of Severe ... Acute Liver Injury ... injury - Viral ... deficiency #LiverInjury ... #Differential #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... involvement, Kidney injury ... for alternative causes ... #DrugInduced #Liver ... #Algorithm #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Injury (DILI) ... dose dependent injury ... differential #Diagnosis #Management ... gastroenterology #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... Injury (DILI) ... Hepatitis Procedures Management ... Failure #Cirrhosis #Hepatology ... gastroenterology #management
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... Algorithm Vascular Causes ... • Iatrogenic: DILI ... Unconjugated Bili ... diagnosis #algorithm #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
= nonspecific (nausea ... 10x ULN), ↑Tbili/Dbili ... Intrahepatic Cholestasis Management ... #Pregnancy #hepatology ... obgyn #diagnosis #management
Alcoholic Hepatitis - Management Algorithm
Assess Eligibility for Treatment:
 - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis - Management ... exclude other causes ... - Acute kidney injury ... HCV, DILI, HCC, ... #Algorithm #hepatology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... Related Acute Lung Injury ... eruptions, diarrhea, liver ... Transfusion #diagnosis #management ... #hematology #reactions