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diagnosis function tests transaminitis algorithm chemistry drug gastroenterology idiosyncratic induced laboratory management rvalue values
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Injury (DILI) ... dose dependent injury ... Chronic - ongoing ↑ LFTs ... #differential # ... gastroenterology #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Differential Diagnosis ... (>1000): • DILI ... injury) • Ischemic ... Diagnosis #hepatology
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
(LFTs) - Normal ... Values and Interpretation ... hepatocellular injury ... Function #Tests #LFTs ... #diagnosis #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
- Interpretation ... of LFTs R-value ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... interpretation
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