10 results
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
(AFLP) Three syndromes ... child * Severe cases ... #AFLP #obstetrics ... #hematology #diagnosis ... #table #comparison
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... or AST > ALP): ... Wilsons, Pregnancy - AFLP ... , HELLP • Moderate ... Algorithm #diagnosis #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... of Pregnancy (AFLP ... iMedEducation #AFLP ... #Fatty #Liver # ... Pregnancy #hepatology
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
child * Severe cases ... plasma exchange 2) Fatty ... #AFLP #Obstetrics ... #OBGyn #Hematology ... Diagnosis #Comparison #Table
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Algorithm Vascular Causes ... • Pregnancy: HELLP ... : • ALP - Surface ... disease - If ALP ... diagnosis #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
phos/ULN ALP) ... • Liver injury ... specificity to elevated ALP ... GGT/5-NT: ↑ • ALP ... #differential #Hepatology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
, no necrosis HELLP ... hemorrhage Acute Fatty ... (AFLP) • Onset ... Disease #Pregnancy #hepatology ... #AFLP
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... • Pregnancy - AFLP ... , HELLP Moderate ... Others #LFTs #Hepatology ... Diagnosis #Algorithm #Causes
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... initial response to abnormal ... ALP, alkaline phosphatase ... non-alcoholic fatty ... #Algorithm #Hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
intralobular bile ducts causes ... cholestasis → Cirrhosis/Liver ... obstruction • ALP ... or higher • Liver ... diagnosis #workup #hepatology