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Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Disease: Primary Biliary ... Cirrhosis vs Primary ... Cholangitis #pathophysiology ... psc #hepatology #comparison
"Liver palms"
Palmar erythema 

#clinical #diagnosis #PhysicalExam 
#hands #liver #hepatology #cirrosis
#photo
"Liver palms" Palmar ... #clinical #diagnosis ... PhysicalExam #hands #liver ... #hepatology #cirrosis ... #photo
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Etiologies of Cirrhosis ... congenital - Primary biliary ... cirrhosis - α1 ... Nonalcoholic fatty liver ... 14 percent) #Diagnosis
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... Cirrhosis (PBC) ... 65 years PBC Pathophysiology ... /Liver failure ... or higher • Liver
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
Primary Biliary ... Cirrhosis - Diagnosis ... Liver biopsy findings ... #PBC #Primary #Biliary ... #Cirrhosis #Diagnosis
Ascites - Differential Diagnosis
Chronic liver disease (cirrhosis or chronic hepatitis) - 80%
Underlying malignancy - 10%
Congestive heart
- Differential Diagnosis ... Chronic liver disease ... (cirrhosis or chronic ... failure - 3-5% Cirrhosis ... Failure, Pancreatic, Biliary
Clinical Examination for Liver and Biliary Diseases
1) Hands: Clubbing, Dupuytren's contracture, Leuconychia, Bruising, Flapping tremor (hepatic
Examination for Liver ... and Biliary Diseases ... #physicalexam #cirrhosis ... #liver #disease ... #signs #diagnosis
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
- Differential Diagnosis ... sarcoidosis) • Liver ... metastasis • Fatty liver ... pregnancy • Primary biliary ... #Differential #Diagnosis
Diagnosis of ascites according to the serum ascites albumin gradient (SAAG)
SAAG ≥ 1.1:
 - Ascitic protein
Diagnosis of ascites ... protein ≤ 2.5 g/dL: Cirrhosis ... syndrome, Massive liver ... syndrome SAAG < 1.1: Biliary ... #differential #diagnosis
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
- Differential Diagnosis ... Non-Malignant • Fatty Liver ... Cholangitis • Primary Biliary ... Cirrhosis #Hepatomegaly ... #Differential #Diagnosis