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Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Idiosyncratic Drug-induced ... presentation • Chronic ... #DILI #Drug #induced ... #gastroenterology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Hepatitis (AAH) Drug-Induced ... Liver Injury (DILI ... #ACLF #Acute #Chronic ... Cirrhosis #Hepatology #gastroenterology
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Chronic progressive ... Drug-induced hyperkalemia ... ACE-Is and ARBs ... exchange resins #aniongap ... diagnosis #causes #nephrology
In ARDS, we know that the lungs are so diffusely injured that the remaining total area
In ARDS, we know ... are so diffusely injured ... of Ventilator-Induced ... pathophysiology #diagnosis #management ... criticalcare #treatment
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
proximal weakness, arms ... Penicillamine induced ... inhibition - Chronic ... Gravis #diagnosis #management ... #neurology
Amiodarone Induced Lung Toxicity Summary

Who?
• 5% of patients
• Dose ≥ 400 mg per day

How?  Possible
cytotoxic lung injury ... organizing pneumonia, ARDS ... • Chronic toxicity ... (e.g., chronic ... Pulmonary #diagnosis #management
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Diagnosis and Management ... Medications: K+, ACEi/ARBs ... , rhabdo/crush injury ... vasopressor or HyperK-induced ... Treatment #potassium #nephrology
Neuromuscular Blockade (Paralytics) and Monitoring

Neuromuscular blockade caring for patients with severe ARDS and may reduce mortality.
patients with severe ARDS ... prevention of patient induced ... lung injury (e.g ... #criticalcare # ... ARDS #management