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diagnosis management differential causes rhabdomyolysis acute anemia aplastic apml cancer chronic classification cll differentiation kidney leukemia leukostasis lymphocytic lysis summary
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
Acute Kidney Injury ... change disease • Hematologic ... malignancies Treatment ... #AKI #Cancer #Oncology ... Classification #Nephrology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... fever - ACS, AKI ... WBC >100k, + lab signs ... #TLS #diagnosis ... #management #hematology
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
, Compartment syndrome ... , Electrical injury ... HIV, Influenza, TSS ... Dermatomyositis) AKI ... - Pathophysiology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
- Compartment syndrome ... HIV, Influenza, TSS ... declines > ALT) • AKI ... + myoglobin AKI ... #nephrology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Pathophysiology ... diagnosis #management #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Marrow (Toxic injury ... Constitutional Syndromes ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... microglobulin Treatment ... • Richter’s Syndrome ... diagnosis #workup #oncology ... #hematology
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