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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Erythematosus #SLE #hematology ... #rheumatology # ... differential #diagnosis
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Thrombocytosis - Differential ... deficiency) • Infection ... Sepsis • Non-infectious ... (malignancy, rheumatologic ... causes #Platelets #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... → Refer to hematology ... Inflammatory Conditions: Rheumatologic ... Thrombocytosis #Platelets #Differential ... Diagnosis #Algorithm #hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
Pancytopenia - Differential ... and non-hematologic ... malignancies • Infection ... #Neutropenia #Differential ... Algorithm #Causes #Hematology
Causes of Leukocytosis and Leukopenia - Differential Diagnosis
 • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
and Leukopenia - Differential ... Connective Tissue, Infections ... Lymphocytosis: Infection ... Leukocytosis #Leukopenia #Differential ... Diagnosis #causes #hematology
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm
 • Reactive (Inflammatory / Infectious)
 •
Lymphadenopathy - Differential ... Inflammatory / Infectious ... Lymphadenopathy #LAD #Differential ... Algorithm #Causes #Hematology
Isolated Neutropenia - Differential Diagnosis Algorithm
Chronic (>3 months):
 • Extrinsic: Vitamins
 • Intrinsic: Congenital, Inflammatory
Transient:
 •
Neutropenia - Differential ... Inflammation: Infectious ... , Non-infectious ... #Neutropenia #Differential ... Diagnosis #Algorithm #hematology
Causes of Hemolytic Anemia - Differential Diagnosis
Inherited
 • Membrane
 • Internal
    - Hemoglobin
Hemolytic Anemia - Differential ... Internal - Infectious ... Hemolytic #Anemia #Differential ... Diagnosis #Causes #hematology
Pancytopenia - Differential Diagnosis Algorithm

#Pancytopenia #Differential #Diagnosis #Algorithm #hematology
Pancytopenia - Differential ... #Pancytopenia #Differential ... Diagnosis #Algorithm #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Thrombocytosis - Differential ... Myelofibrosis Infectious ... Non malignant hematologic ... Thrombocytosis #Differential ... Algorithm #Causes #Hematology