12 results
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
- Differential ... Diagnosis Algorithm ... • Liver (80%) ... #Differential # ... #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
(LFTs) Elevation ... abnormality vs bone ... Transaminase >> Alkaline ... Transaminitis #diagnosis ... #hepatology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Injury • AST/ALT elevation ... + ULN ALT) / (alkaline ... Transaminitis #diagnosis ... #differential # ... hepatology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
synthesized in: liver ... Adult form: Less ... Low ALP in adult ... eliminated • Elevation ... phosphate &/or • Elevation
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Tests - AST, ALT, Alkaline ... Alkaline phosphatase ... Other locations: bone ... hepatocyte - Elevation ... Pathophysiology #Diagnosis
Causes of Hyperferritinemia - Differential Diagnosis
Ferritin > 1000
Ferritin is the storage form of iron. Increased hepcidin
Diagnosis Ferritin ... be used by the bone ... is made in the liver ... Hematologic Malignancy ... extreme ferritin elevation
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
magnitude of enzyme elevation ... ALP, alkaline phosphatase ... aminotransferase; BMI, body ... Abnormal #Algorithm #Hepatology ... #Differential #
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Enzyme Elevation ... hemolysis) • ALP: Bone ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... Diagnosis Algorithm ... Enzyme Elevation ... hemolysis) • ALP: Bone ... #hepatology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
Epidemiology: young adults ... the spleen or liver ... Diagnosis of B-Symptoms ... #differential # ... hematology