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management differential hemophagocytic hepatology hlh lymphohistiocytosis neurology rheumatology syndrome treatment alkaline anorexianervosa arterial bandemia barre cbc coagulation comatose complications crisis
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... changes), high MCV anemia ... evaluation: not required ... in all patients ... #hematology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Most cases diagnosed ... • Pernicious anemia ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Incidence: 1 to 2 cases ... complete paralysis of all ... the underlying pathophysiology ... ventilation is required ... #management #neurology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
- Differential Diagnosis ... THROMBOSIS • Acquired ... considered in all ... Venous #Arterial #pathophysiology ... #hematology #differential
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Differential Diagnosis ... science/article/abs ... hypotension or septic shock ... neutrophil #WBC #CBC #hematology ... #pathophysiology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Griscelli, Purtilo (XLP ... ) Acquired HLH: ... Drugs, Unknown cause ... treatment #summary #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... dysfunction (16%) • Shock ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... count ↑ PLT • ↑ PBS ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
The Neurological Evaluation of a Comatose Patient Definition: • Coma: a state of unresponsiveness; the absence of
Differential Diagnosis ... • Mutism Pathophysiology ... stimulation to all ... Casey Albin MD @ ... #comatose #diagnosis
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
microangiopathic hemolytic anemia ... (MAHA) Pathophysiology ... • Refractory cases ... Renal #Crisis #rheumatology ... #nephrology #diagnosis
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