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management pharmacology cap diagnosis infectiousdiseases overview pneumonia azithromycin bactrim cdi cdiff clarithromycin clostridioides clostridium cns coverage csf days difficile durations
Antibiotic treatment durations for first line antibiotics recommended by Public Health England (PHE) guidance • Acute
Antibiotic treatment ... acquired pneumonia ... CRB65=0 7 days • Community ... acquired pneumonia ... and CRB65=1 7-10
Antibiotics for severe community-onset pneumonia Atypical coverage always - Usually azithromycin 500 mg daily - Doxycycline
severe community-onset ... piperacillin-tazobactam Septic Shock ... Hospitalization for > 1 ... - Linezolid 1 ... #Acquired #Pneumonia
CSF Penetration of Antimicrobials Despite the poor CSF penetration, beta-lactams have the most research documenting successful treatment
Penetration of Antimicrobials ... of community-acquired ... compared to other antibiotic ... classes. 1 only ... Penetration #CNS #Antimicrobials
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
Toxic Megacolon, Shock ... Epidemiology: • #1 ... post-ABx, but can be community-acquired ... Ileus, Megacolon, Shock ... 10 mg/kg IV x 1
Community Acquired Pneumonia (CAP) - Diagnosis and Management Pneumonia Signs/Symptoms: • Confusion/disorientation (LR + 1.9) • Cough
Community Acquired ... Egophony (May appear 1- ... 96.1% • Empiric antibiotic ... procalcitonin level Treatment ... #Pulmonary #Community
Macrolides - Erythromycin, Clarithromycin, Azithromycin - Antibiotics Class Overview 50S Ribosomal Inhibitor (PO and IV) Spectrum: Atypical organisms
Azithromycin - Antibiotics ... exacerbations, community-acquired ... Used for MAC treatment ... #Pharmacology #Antibiotics ... #Review #Overview
Sulfonamides - Antibiotics Class Overview BACTRIM/SEPTRA (TMP/SMX) - inhibit sequential steps in Folate synthesis --> bacteriostatic Spectrum: Wide
Sulfonamides - Antibiotics ... choice, both for treatment ... prophylaxis), Community-acquired ... #Pharmacology #Antibiotics ... #Review #Overview
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