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management diagnosis infectiousdiseases pharmacology antimicrobials candida cdi cdiff clostridioides clostridium cns csf difficile esophageal fungal gastroenterology hemophagocytic hivaids hlh lymphohistiocytosis
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
Clostridioides Difficile Infection ... Toxic Megacolon, Shock ... nosocomial infection ... post-ABx, but can be community-acquired ... #Clostridium #Infection
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Triggering factor (infection ... Purtilo (XLP) Acquired ... HLH: • Infections ... Still disease, Infection ... Etiological+++: Anti-infectious
IDSA Recommendations for Treating Mucosal Candidiasis in HIV-AIDS Oropharyngeal Candidiasis: Initial Episodes (Duration of Therapy: 7–14 days) Preferred
IDSA Recommendations ... 4–6 mL QID or 1– ... antifungals are required ... candida #mucosal #IDSA ... opportunistic #infections
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
Mycoses HISTOPLASMOSIS ... Disseminated Infections ... 50% in chronic infection ... clinical forms: 1) ... fever • Septic shock
CSF Penetration of Antimicrobials Despite the poor CSF penetration, beta-lactams have the most research documenting successful treatment
of community-acquired ... antibiotic classes. 1 ... in clinical CNS infections ... susceptible CNS infections ... of CNS infections
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