19 results
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
hemorrhage) • Chronic ... disorders (e.g. autoimmune ... Myelodysplastic syndrome ... Myelofibrosis (MF) • Chronic ... Diagnosis #Causes #hematology
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... less systemic symptoms ... , holster sign, ... anti-synthetase syndrome ... Myositis #diagnosis #rheumatology
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
(vasculitis / autoimmune ... Hypereosinophilic Syndrome ... - Chronic Eosinophilic ... Diagnosis #Causes #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Chronic Lymphocytic ... Splenomegaly 5) Symptoms ... Constitutional symptoms ... uw_IMresidency #CLL #Chronic ... Leukemia #oncology #hematology
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
Autoimmune diseases ... and duration of symptoms ... , Hypotension, shock ... Atopic diseases, Chronic ... Urticaria #diagnosis #rheumatology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Dehydration • Symptoms ... changes, stroke symptoms ... WBC >100k, + lab signs ... tumor burden • Symptoms ... diagnosis #management #hematology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Autoimmune → Inflammation ... noninflammatory Signs ... constitutional symptoms ... Rheumatologic Disease ... Diagnosis #MSK #rheumatology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Autoimmunity • Chronic ... : • Nephrotic syndrome ... Malignancies • Chronic ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral infection, autoimmune ... (Cold-induced symptoms ... CLL (older) • Autoimmune ... hemolytic #anemia #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... with no early symptoms ... Physical Exam/Signs ... • Richter’s Syndrome ... workup #oncology #hematology