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diagnosis differential management ana antinuclear autoantibodies classification erythematosus fungal hematology hemeonc hemophagocytic hlh infections infectiousdiseases lupus lymphohistiocytosis mimickers mycoses myopathy
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Systemic Sclerosis ... autoimmune disease ... and Symptoms: ... #SSc #rheumatology ... #diagnosis #signs
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... Positive ANA ≠ Autoimmune ... context of other symptoms ... ANA #patterns #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
SLE-Related Auto-Antibodies ... malignancies, Multiple sclerosis ... autoantibodies #signs ... #symptoms #mimickers ... #differential #rheumatology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
• Rheumatologic ... • Sclerosing mediastinitis ... for Blastomyces antibodies ... for Coccidioides antibodies ... fever • Septic shock
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Symptoms (Sx) in ... , particularly scleritis ... purpura: strong sign ... C-ANCA) pattern: antibodies ... differential #diagnosis #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... papules and Gottron sign ... ) • Shawl sign ... • Conduction system ... Myositis #Myopathy #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
of the immune system ... Malignancies ▪ Autoimmune ... Presentation • Common Signs ... and Symptoms: ... inhibitors, anti-IFN-γ antibodies
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