Intraoperative diagnosis pathophysiology syndrome signs anesthesia rheumatology sle hematology dermatology symptoms arthritis antibodies hemolytic anemia cll erythematosus

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Systemic Lupus Erythematosus - Diagnosis
Manifestations:
- Arthritis 69%
- Malar rash 40%
- Fever 36%
-

: - Arthritis ... anemia 4% - Myositis ... Auto-Antibodies ... #signs #symptoms ... #differential #rheumatology

Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin

of hip (rare), Arthritis ... Demyelinating syndromes ... ) Blood (75%): Anemia ... #signs #symptoms ... #diagnosis #rheumatology

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

Cold Sensitive Antibodies ... Cold Agglutinin Syndrome ... Diagnosis: • hemolytic ... anemia • Cold ... #anemia #hematology

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

Differential Diagnosis ... Non-autoimmune rheumatologic ... lymphopenia, low PLT • Anemia ... Induced Lupus: • Symptoms ... #Diagnosis #Rheumatology

Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
• Lymphocytes accumulate in large numbers

non-Hodgkin lymphoma SLL ... with no early symptoms ... Physical Exam/Signs ... • Neutropenia, anemia ... workup #oncology #hematology

Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
•

Presentation - Systemic Symptoms ... purpura: strong sign ... C-ANCA) pattern: antibodies ... vasculitis, and SLE ... #rheumatology #

Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,

diseases, such as SLE ... purpura: Strong sign ... ischemia • Skin: Erythematous ... • Progressive symptoms ... #Rheumatology

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