10 results
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... have extra nodal involvement ... Low Grade - Slow growing ... Lymphoproliferative #Disorders #Classification ... #differential #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... , arthritis LARGE ... nervous system involvement ... Vessel Size: • Large ... #rheumatology #classification
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
on bone marrow leading ... or testicular involvement ... • 30%: CNS involvement ... -> AML: Blast crises ... aggressive form of large
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
discrepancies LARGE ... CRP GCA (Giant Cell ... tract, and often causes ... nervous system involvement ... chorioretinitis, CNS large
Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations
Clinical Classification ... Diastolic dysfunction ... pulmonary Langerhans cell ... neurofibromatosis, vasculitis ... #Differential #Causes
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Thromboembolism (7%) • CNS involvement ... Schistocytes, helmet cells ... Treat primary cause ... if presence of large ... Coagulation #diagnosis #causes
Langerhans Cell Histiocytosis (LCH)

Granulomatous Lesions comprising langerin-positive histiocytes and an inflammatory infiltrate can arise in virtually
various tissues, leading ... • Endocrine Dysfunction ... marrow: Organ dysfunction ... Immunophenotyping: • Large ... for endocrine dysfunctions
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... swelling CNS Involvement ... ) • Cutaneous vasculitis ... : 2% Systemic Vasculitis ... lymphoma • Large
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... Angioimmunoblastic T-cell ... the small and large ... mild cognitive dysfunction ... : • Chronic B-cell
Common Malignancies That Cause Ascites
The most common malignancies causing ascites are ovarian cancer, pancreatic cancer, gastric
presents with large-volume ... - Signet ring cell ... direct peritoneal involvement ... CARCINOMATOSIS - Tumor cells ... malnutrition or liver dysfunction