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diagnosis hematology differential management rheumatology coagulation dic disorders disseminated erythematosus histiocytosis intravascular langerhans lch lupus lymphomas lymphoproliferative nonhodgkin oncology pathophysiology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
on bone marrow leading ... or testicular involvement ... • 30%: CNS involvement ... -> AML: Blast crises ... aggressive form of large
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... have extra nodal involvement ... Treated Like Acute Leukemias ... Lymphoproliferative #Disorders #Classification ... #differential #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... , arthritis LARGE ... nervous system involvement ... Vessel Size: • Large ... #rheumatology #classification
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... Thromboembolism (7%) • CNS involvement ... Schistocytes, helmet cells ... Treat primary cause ... if presence of large
Langerhans Cell Histiocytosis (LCH) Granulomatous Lesions comprising langerin-positive histiocytes and an inflammatory infiltrate can arise in virtually
various tissues, leading ... • Endocrine Dysfunction ... marrow: Organ dysfunction ... Immunophenotyping: • Large ... for endocrine dysfunctions
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... the small and large ... mild cognitive dysfunction ... : • Chronic B-cell ... Hodgkin lymphoma and leukemia
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