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diagnosis differential liver management hepatitis acute aflp aki alcoholic bilirubin congenital distention drug druginduced fatty hyperbilirubinemia idiosyncratic induced inherited kidney
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Diagnosis Algorithm ... for alternative causes ... disease, Hepatic ischaemia ... disorder (e.g. ascites ... #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Drug-induced Liver Injury ... dose dependent injury ... Diagnosis #Management #gastroenterology ... #algorithm #gastroenterology ... #hepatology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Acute Kidney Injury ... Artery Stenosis, Abdominal ... Other • ATN: Ischemia ... Diagnosis #nephrology #causes ... #algorithm
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... • Iatrogenic: DILI ... differential #diagnosis #algorithm ... #hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
= nonspecific (nausea ... , vomiting, abdominal ... develops (DIC, ascites ... 10x ULN), ↑Tbili/Dbili ... Liver #Pregnancy #hepatology
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
>20) - Obtain abdominal ... exclude other causes ... - Acute kidney injury ... HCV, DILI, HCC, ... #hepatology
Abdominal Distention - Differential Diagnostic Algorithm Ascites Bowel Dilatation Other Causes Mechanical Obstruction • Adhesions 60% • Volvulus 3% •
Abdominal Distention ... Ascites Bowel ... Dilatation Other Causes ... Infectious • Ischemic ... Sclerosis, Spinal Injury
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
hemolysis or liver injury ... symptoms, such as abdominal ... and stress may cause ... Congenital #bilirubin #hepatology ... #diagnosis #gastroenterology
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