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diagnosis differential liver lfts transaminitis aki alcoholic druginduced elevated function hepatocellular kidney liverenzymes liverinjury management nephrology severe tests transaminases
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Causes of Severe ... Acute Liver Injury ... - Ichemic hepatitis ... - Autoimmune ... #Hepatology #Diagnosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
for alternative causes ... disease, Hepatic ischaemia ... dechallenge • Acute ... hepatitis #DILI ... #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Hepatopathy • Acute ... (>1000): • DILI ... Drug-induced liver injury ... ) • Ischemic Hepatopathy ... Differential #Diagnosis #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
obstruction syndrome • Autoimmune ... : DILI, Tylenol, ... See Updated Schema ... Differential #Diagnosis #causes ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Vascular Causes ... : Autoimmune hepatitis ... • Iatrogenic: DILI ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Other: NAFLD, Autoimmune ... hepatitis, Acute ... #Acute #algorithm ... #hepatology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Acute Kidney Injury ... Other • ATN: Ischemia ... Medication, Infection, Autoimmune ... Diagnosis #nephrology #causes ... #algorithm
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
• Vascular: Ischemic ... Other: NAFLD, Autoimmune ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Drugs/Toxins • Ischemia ... • Autoimmune ... • Alcoholic hepatitis ... Others #LFTs #Hepatology ... #Causes
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... exclude other causes ... kidney injury with ... HCV, DILI, HCC, ... #hepatology
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