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diagnosis differential lfts transaminitis hbv hepatitisb aih alcoholic autoimmune chemistry cirrhosis dili druginduced failure function gastroenterology hepbv indications interpretation patterns
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Injury (DILI) ... #Acute #Chronic ... #Cirrhosis #Hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... Injury Transaminase ... 20x normal - Acute ... 5-10x normal - Chronic ... #Injury #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Cirrhosis • Chronic ... Viral Hepatitis ... Hepatopathy • Acute ... injury) • Ischemic ... Differential #Diagnosis #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... non-essential drug/HDS treatments ... disease, Hepatic ischaemia ... dechallenge • Acute ... #Algorithm #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... Algorithm • ... Chronic Hepatitis ... #Management #Treatment ... #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... > 3 • Chronic ... #injury #hepatitis ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
viral hepatitis ... ALF): • Liver ... > 2 • NASH, Chronic ... > 3 • Chronic ... #differential #Hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
subclinical disease to acute ... - Symptoms of chronic ... injury, though ... regarding need for treatment ... #Hepatology
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
Hepatitis B - Treatment ... injury (INR > 2 ... liver failure ... #Indications #management ... #hepatology
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... - Management Algorithm ... injury with serum ... #Management #Algorithm ... #hepatology
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