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diagnosis differential liver lfts injury causes elevated management abnormal aclf albumin alcoholic ascites chemistry chronic druginduced failure function gastroenterology gradient
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
• NAFLD • Cirrhosis ... Hepatopathy • Acute ... (>1000): • DILI ... liver injury) • Ischemic ... #transaminitis
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
> 50x normal - Ischemic ... 20x normal - Acute ... CMV), Alcoholic cirrhosis ... Liver #Injury #hepatology ... #LFTs #transaminitis
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Transaminases / Transaminitis ... • Autoimmune hepatitis ... • Iatrogenic: DILI ... See Updated Schema ... Diagnosis #causes #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... disease, Hepatic ischaemia ... dechallenge • Acute ... • Autoimmune hepatitis ... #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... those with CLD (± cirrhosis ... Liver Injury (DILI ... ) Viral Hepatitis ... #Hepatology #gastroenterology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Differential Diagnosis Algorithm ... for Transaminitis ... Drugs, Viral, Ischemia ... Congenital, Others, Cirrhosis ... #hepatology #LiverFunctionTests
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... • Iatrogenic: DILI ... : < 1 • Cirrhosis ... differential #diagnosis #algorithm ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
viral hepatitis ... viral hepatitis ... : < 1 • Cirrhosis ... #differential #Hepatology ... #transaminitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Differential Diagnosis Algorithm ... Drugs/Toxins • Ischemia ... • Alcoholic hepatitis ... Infiltrative • Cirrhosis ... Others #LFTs #Hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
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