10 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver Injury ... - Ischemic Hepatitis ... Patterns #Liver #Injury ... #hepatology #LFTs ... #differential #diagnosis
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • Drugs • AIH ... hepatitis • Drugs ... Others #LFTs #Hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
- Differential Diagnosis ... Drugs, Viral, Ischemia ... kwburak #LFTs #Elevated ... #Algorithm #diagnosis ... #hepatology #LiverFunctionTests
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Failure Infections Alcohol-Associated ... Hepatitis (AAH) ... Drug-Induced Liver Injury ... Failure #Cirrhosis #Hepatology ... gastroenterology #management #diagnosis
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... #hepatology #algorithm ... Transaminitis #LFTs #hepatitis
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
- Differential Diagnosis ... upon damage • Normal ... • Ischemic hepatitis ... fever) • Drugs (alcohol ... #differential #diagnosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Algorithm DILI ... HEV, EBV, CMV), Alcohol-related ... disease, Hepatic ischaemia ... #Diagnosis #Algorithm ... #hepatology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
pattern of liver injury ... IgG typically elevated ... , AIH diagnosis ... #AIH #Diagnosis ... #Management #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Algorithm Vascular ... specificity to elevated ... ALT Ratios: • Alcoholic ... #diagnosis #algorithm ... #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Liver Failure (ALF ... specificity to elevated ... ALT Ratios: • Alcoholic ... liver #chemistry #diagnosis ... #differential #Hepatology